Nutrition
for Women
• 100% Natural
• Cold Processed
HOW PATIENTS MAY BENEFIT
- Helps provide nutritional support to women
with PMS*
PRODUCT DISCUSSION
PhysioLogics Evening Primrose Oil (EPO) supplies 45 mg of Gamma-Linolenic Acid (GLA)
per softgel and up to 270 mg per day to help provide nutritional support for
overall health and for women with PMS.* GLA is an omega-6 fatty acid that can be
synthesized from Linoleic Acid in the body by the rate-limiting enzyme delta-6
desaturase. However, biological conversion is estimated to be less than 10% and
is affected by several factors, including aging; intake of certain nutrients
such as zinc, B6, magnesium, biotin and calcium; stress; and cholesterol levels.
GLA does not have significant food sources, so supplementation may be important.
STRUCTURE AND FUNCTION
GLA promotes cellular and metabolic health.* It is a precursor to prostaglandins,
action-specific bio-molecules that regulate many important functions in cells,
and provides nutritional support for women with PMS by modulating prostaglandin
production.* GLA also supports the immune system and can help with dry skin.*
CLINICAL EVIDENCE
- Fourteen subjects were assessed for effects on
skin health after receiving capsules of evening primrose oil containing 40
mg of gamma linolenic acid (GLA) per capsule twice per day. All subjects
reported improvements in skin health, with 42.8% subjects having complete
improvement in skin health. (Yoon et al, 2002)
- In a preliminary clinical trial with 68 women
who had a history of PMS, 500 mg of EPO taken twice daily led to an overall
positive effect on PMS scores, which were based on mood, mental well-being,
comfort, and fluid retention. Over 60% of the women who had poor success
with PMS previously had a reported "good" response to EPO when
compared to placebo. (Brush et al, 1984)
SUMMARY
PhysioLogics Evening Primrose Oil is a source of Gamma-Linolenic Acid and
provides nutritional support for overall health and for women with PMS.*
SUGGESTED DOSAGE
For adults, take one (1) softgel three to six times daily, preferably with
meals, or follow the advice of a health care professional.
REFERENCES
Brush MG, Watson SJ, Horrobin DF, Manku MS. Abnormal essential fatty acid
levels in plasma of women with premenstrual syndrome. Am J Obstet Gynecol.
1984;150:363-6.
Yoon S, Lee J, Lee S. The therapeutic effect of
evening primrose oil in atopic dermatitis patients with dry scaly skin lesions
is associated with the normalization of serum gamma-interferon levels. Skin
Pharmacol Appl Skin Physiol. 2002;15:20-5.
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