Promotes
Joint Comfort & Mobility*
HOW PATIENTS MAY BENEFIT
- Increases mobility and range of motion*
PRODUCT DISCUSSION
PhysioLogics MSM contains Methylsulfonylmethane (MSM), an organic source of
sulfur, a mineral that is vital in the formation of collagen, connective tissue,
and healthy joint cartilage.* It is one of the top three ingredients found in
popular joint products.
STRUCTURE AND FUNCTION
Sulfur plays an important role in nutrition. It is the eighth most abundant
element, and is an integral component of more than 150 compounds in the body.
Sulfur is fundamental to the structure and integrity of certain tissues,
including hair, skin, nails, and joints.* MSM is a dietary source of sulfur that
is found widely in nature; major sources include milk, eggs, seafood, meats and
plants.
MSM clinical trials have focused on cartilage and joint support.* Cartilage
is a fibrous, elastic connective tissue that functions as a cushioning layer for
joints and is comprised of an extracellular matrix made of complex proteins
known as glycosaminoglycans (GAGs) and proteoglycans. Sulfur is used in the body
as a constituent of certain amino acids, collagen and disulfide bonds, and
provides a raw material for the production of GAGs and collagen.*
CLINICAL EVIDENCE
- 118 subjects participated in a clinical trial in which they received 500
mg of MSM or placebo 3 times per day for 12 weeks. Those receiving MSM
experienced a significant increase in joint comfort compared with the
placebo group. Our product provides up to 3 grams of MSM per day. (Usha and
Naidu, 2004)
- 40 subjects completed a clinical trial in which they received 3 g of MSM
or placebo twice per day for 12 weeks. Those receiving MSM experienced
significant improvements in joint comfort and function compared with
placebo. Our product provides up to 3 grams of MSM. (Kim et al. 2006)
SUMMARY
Sulfur is one of the building blocks of collagen and GAGs, key structural
components in cartilage.* The compounds play an important role in the integrity
and maintenance of joint cartilage.* MSM is a natural dietary source of sulfur
which helps support the health of joints and cartilage.*
SUGGESTED DOSAGE
For adults, take one (1) capsule two to three times daily (1000 mg), preferably
with meals, or follow the advice of a health care professional.
REFERENCES
Beilke MA, Collins-Lech C, Sohnle P. Effects of dimethyl sulfoxide on the
oxidative function of human neutrophils. J Lab Clin Med. 1987;110:91-6.
Jacobs B. MSM packs a sulfuric punch. Nutr Sci Rev. 1999;4:232-4.
Kim LS et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis
pain of the knee: a pilot clinical trial. Osteoarthritis and Cartilage. 2006.
14(3):286-294.
Oae S, Okuyama T. Organic sulfur chemistry: biochemical aspects. Boca
Raton, FL:CRC Press, 1992.
Parcell S. Sulfur in human nutrition and applications in medicine. Altern
Med Rev. 2002;7:22-44.
Sharif M, Osborne DJ, Meadows K, et al. The relevance of chondroitin and
keratan sulphate markers in normal and arthritic synovial fluid. Br J
Rheumatol. 1996;35:951-7.
Usha PR and Naidu MUR. Randomised, double-blind, parallel,
placebo-controlled study of oral glucosamine, methylsulfonylmethane and their
combination in osteoarthritis. Clinical Drug Investigation. 2004.
24(6):353-363.
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