Promotes Cartilage Renewal*

PRODUCT DISCUSSION
PhysioLogics Chondroitin Sulfate provides 500 mg per capsule and 1,500 mg per day of Chondroitin, a compound that promotes healthy enzymatic metabolism of cartilage.*

STRUCTURE AND FUNCTION
Chondroitin Sulfate is a natural constituent of cartilage, made up of repeating chains of glycosaminoglycans (GAGs). Chondroitin Sulfate is a highly charged polyanion, promoting water retention in the connective tissue to support joint flexibility and cushion joints.* Composed of Nacetyl-galactosamine and glucuronic acid, Chondroitin Sulfate provides a raw material for proteoglycan and GAG synthesis to actually help renew cartilage.* Chondroitin Sulfate also promotes healthy enzymatic metabolism of cartilage, to further maintain joint health.*

CLINICAL EVIDENCE

• A total of 120 subjects were given 800 mg Chondroitin Sulfate or placebo for two, three-month periods over the course of a year. Subjects receiving Chondroitin Sulfate had significantly improved knee function as compared to the placebo group. (Uebelhart et al, 2004)
• Another placebo-controlled study showed that subjects consuming 1 g/day Chondroitin Sulfate had significantly improved joint comfort and overall joint health (Lequesne’s algofunctional index, AFI) when compared to placebo. (Mazieres et al, 2001)

SUMMARY
Chondroitin Sulfate promotes healthy enzymatic metabolism of cartilage to maintain joint health.

SUGGESTED DOSAGE
For adults, take one (1) capsule three times daily, preferably with meals, or follow the advice of a health care professional.

REFERENCES
Bucsi L, Poor G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage. 1998;6 Suppl A:31-6.

Mazieres B, Combe B, Phan Van A, et al. Chondroitin sulfate in osteoarthritis of the knee: a prospective, double blind, placebo controlled multicenter clinical study. J Rheumatol. 2001;28:173-81.

Uebelhart D, Malaise M, Marcolongo R, et al. Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo. Osteoarthritis Cartilage. 2004;12:269-76.