Supports the Body’s Immune System*

HOW PATIENTS MAY BENEFIT

• Supports respiratory and digestive systems.*
• Favorably modulates prostaglandin formation.*

PRODUCT DISCUSSION
PhysioLogics PTE Support™ is a scientifically-formulated supplement to support digestion and absorption of proteins, as well as provide the body with immune-modulating and respiratory support.* Each serving of PhysioLogics PTE Support™ is standardized to provide 1200 Gelatin Digesting Units from 500 mg of Bromelain (derived from pineapple) to ensure protein-digesting quality.* Ingredients can be absorbed into the bloodstream, providing more than just digestive support.* PTE Support™ can be used by clients who may be increasing protein intake and need extra digestive support, or who need support of the sinus and respiratory systems for ear, nose and throat health.*

STRUCTURE AND FUNCTION
Bromelain is a general name for a family of proteolytic enzymes obtained from pineapple (Ananas comosus). Proteolytic enzymes help break down dietary proteins in the digestive tract, as well as unwanted protein compounds in the bloodstream. Bromelain’s primary component is a sulfhydryl proteolytic fraction, but bromelain also contains peroxidase, acid phosphatase, protease inhibitors, and organic calcium.

Bromelain serves to modulate the coagulation system by several methods. It decreases the production of Prekallikein, thereby decreasing the production of High Molecular Weight Kinin (HMWK), and subsequently Bradykinin. It decreases the production of Factor X, prothrombin (II), and activates the conversion of plasminogen to plasmin. Bromelain has also been shown to modulate the synthesis of thromboxanes and prostacyclins.

Serratiopeptidase (also known as serrapeptase) is a proteolytic enzyme that can be absorbed into the blood to provide its beneficial effects. It is found in nature as the enzyme produced by silkworms to digest their cocoons. The capacity of serratiopeptidase to dissolve protein selectively without affecting normal function makes it a great agent for a broad spectrum of health benefits. This can be important when the body has undergone physical stress, by helping to reduce unwanted protein compounds that can otherwise slow recovery.*

Serratiopeptidase enzyme supports the sinus and respiratory systems to promote ear, nose and throat health.* It seems to work by amending the elasticity and viscosity of naturally produced mucus, without causing mucus depletion. Serratiopeptidase has been used in Europe and Japan for over 25 years for its health benefits.*

Bromelain and Serratiopeptides are proteolytic enzymes that effect cellular immune functions and enhance healthy cell growth.*

CLINICAL EVIDENCE

• In an open label trial, 77 subjects were given either 200 mg or 400 mg of Bromelain every day for three months. Results found that the group receiving 400 mg Bromelain had improved knee joint comfort and function compared to the 200 mg group. Bromelain’s positive effect on the immune response most likely contributed to the improved benefits. PTE Support provides 500 mg Bromelain per serving. (Walker, 2002)
• Researchers from the University of Naples in Italy conducted a multicenter, randomized, double blind study to determine the effects of 30 mg of Serratiopeptidase on 193 subjects. Statistical analysis revealed significant support of respiratory health in subjects given Serratiopeptidase as compared to the placebo. (Mazzone, 1990)
• In an open labeled trial researchers examined 29 subjects who received either 30 mg/day of serrapeptase or a placebo. After 4 weeks, the group receiving serrapeptase experienced a significant improvement in respiratory function. There was no significant change in the control group. This study indicates that serrapeptase supports respiratory health. (Nakamura et al, 2003)

SUMMARY
Bromelain has been clinically used in a variety of applications for more than 35 years. It has positive effects on coagulation, the kinin system, cytokine, and prostaglandin synthesis. Bromelain also supports digestion of dietary proteins while supporting a healthy immune response throughout the body.* Serratiopeptidase Enzyme supports the sinus and respiratory systems to promote ear, nose and throat health.*

SUGGESTED DOSAGE
For adults, take one (1) to two (2) capsules three times daily on an empty stomach (1 hour before or 3 hours after a meal) or follow the advice of your healthcare professional.

REFERENCES
Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6:1123-33

Heinicke RM, et al. Effect of bromelain (Ananase) on human platelet aggregation. Experientia. 1972;28:844-5

Livio M, et al. Effect of bromelain on fibrinogen level, prothrombin complex factors and platelet aggregation in the rat- A preliminary report. Drugs Expt Clin Res. 1978;4:49-53

Masson M. Bromelain in blunt injuries of the locomotor system. A study of observed applications in general practice. Fortschr Med. 1995;113:303-6

Mazzone A. Evaluation of serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990;18:379-288

Nakamura S, et al. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Respirology. 2003;8:316-20

Schafer AI, Adelman B. Plasmin inhibition of platelet function and of arachidonic acid metabolism. J Clin Invest. 1985;75:456-61

Tachibana M, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica. 1984;3:526-30

Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol. 1988;22:91-203

Uhlig G, Seifert J. The effect of proteolytic enzymes (traumanase) on posttraumatic edema. Fortschr Med. 1981;99:554-6

Walker A. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in a open study of otherwise healthy adults. Phytomedicine. 2002;9:681-6.