Supports the Nervous System, Energy Cycle and Bones*

PRODUCT IS A MIXTURE OF
Magnesium Glycinate, Magnesium Oxide, Dicalcium Phosphate, Calcium Stearate

PRODUCT DISCUSSION
PhysioLogics’ Magnesium Chelate provides two forms of Magnesium to support cellular energy, promote healthy nerve function, and help maintain strong, healthy bones.*

STRUCTURE AND FUNCTION
Magnesium is an essential ubiquitous cation that plays a fundamental role in more than 300 enzymatic reactions. Necessary for the anatomical and functional integrity of various subcellular organelles, it participates in every major metabolic pathway, including nucleic acid, protein, carbohydrate, and lipid metabolism. As a cofactor of adenosine triphosphatases, Magnesium ions play a fundamental role in the synthesis, transfer, storage and utilization of energy-rich compounds.*

Magnesium supports healthy nerve cell function. Its presence in adequate amounts in the synaptic gap between neurons modulates the rate at which nerves fire. If Magnesium levels are insufficient, neurons fire too easily, resulting in excessive sensitivity to various stimuli. Magnesium is a component of the muscle enzyme creatine kinase and is needed at the neuromuscular junction in order for muscles to relax.*

Magnesium plays a key role in bone health. The human skeleton utilizes 55% of the body’s magnesium. Magnesium directly influences both matrix and mineral metabolism in bone, and aids in the absorption of Calcium by promoting the secretion of calcitonin, a hormone that aids in the influx of calcium into bone. In addition, Magnesium plays a role in modulating the secretion of parathyroid hormone, whose function is to draw Calcium out of bones and deposit it in soft tissue.*

The importance of Magnesium in healthy cardiovascular function has long been recognized. Epidemiological studies found that communities with sufficient levels of Magnesium in drinking water tended to have more support of heart health. Extracellular Magnesium ions exert important effects upon transport and release of Calcium ions in the vascular system, supporting healthy vascular tone.*

INDICATIONS
The National Health and Nutrition Examination Survey (NHANES III-1988-91) and the Continuing Survey of Food Intakes of Individuals (1994 CSFII) suggest that the diets of most adult Americans do not provide the recommended amounts of Magnesium. In addition, certain regularly prescribed drugs may cause Magnesium depletion. PhysioLogics’ Magnesium Chelate may be a desirable dietary supplement for clients who want to support cellular energy synthesis as well as nerve, bone and cardiovascular health.*

HOW CLIENTS MAY BENEFIT

• Maintain proper nerve function and muscle contraction.*
• Magnesium aids in the absorption of calcium into bone and may promote bone mineralization.*
• Vital to the formation and release of energy to the cells as a cofactor of adenosine triphosphatases.*
• Promotes a healthy vascular system.*

SCIENTIFIC RESEARCH

• A study of 12 young healthy men found that daily supplementation with 15mmol (365mg) Magnesium supports bone health, as measured by healthy levels of resorption biochemical markers.
• Magnesium can support a healthy musculature. One recent study found that 100 mg of Magnesium per day for a month promoted exercise tolerance.
• In a double-blind, placebo-controlled study of Magnesium and heart health, Rasmussen, et. al. administered 15mmol (365mg) Magnesium or placebo to 47 patients and monitored cardiovascular health. Those who received Magnesium had significant support of cardiac health.

SUMMARY
Magnesium is an essential nutrient for bone formation and maintenance. PhysioLogics’ Magnesium Chelate provides Magnesium Glycinate in an absorbable form for those who want to ensure they obtain daily supply of this vital mineral to maintain cellular energy levels and support nerve and bone health through all stages of life.*

SUGGESTED DOSAGE
Take 1 caplet up to two times daily, preferably with meals, or follow the advice of your health care professional. As a reminder, discuss the supplements and medications you take with your health care providers.

REFERENCES
Abarbanel HD, Gibb L, Huerta R, Rabinovich MI. Biophysical model of synaptic plasticity dynamics. Biol Cybern. 2003 Sep;89(3):214-26. Epub 2003 Jul 31.

Alaimo K, McDowell, M.A., Briefel, R.R, Bischlf, A.M, Caughman, C.R, Loria, C.M, Johnson, C.L. Dietary Intake of Vitamins, Minerals, and Fiber of Persons Ages 2 Months and Over in the United States: Third National Health and Nutrition Examination Survey, Phase 1, 1988- 91. In: Johnson GV, ed. Vital and Health Statistics of the Center for Disease Control and Prevention / National Center for Health Statistics, Hyattsville, MD 1994:1-28.

Altura BM, Zhang A, Altura BT. Magnesium, hypertensive vascular diseases, atherogenesis, subcellular compartmentation of Ca2+ and Mg2+ and vascular contractility. Miner Electrolyte Metab. 1993;19(4-5):323-36. Review.

Brautbar N, Carpenter C. Skeletal myopathy and magnesium depletion: cellular mechanisms. Magnesium. 1984;3(2):57-62.

Dimai HP, Porta S, Wirnsberger G, Lindschinger M, Pamperl I, Dobnig H, Wilders-Truschnig M, Lau KH. Daily oral magnesium supplementation suppresses bone turnover in young adult males. J Clin Endocrinol Metab. 1998 Aug;83(8):2742-8.

Dreosti IE. Magnesium status and health. Nutr Rev. 1995 Sep;53(9 Pt 2):S23-7.

Ferment O, Touitou Y. Magnesium: metabolism and hormonal regulation in different species. Comp Biochem Physiol A. 1985;82(4):753-8.

Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press. Washington, DC, 1999.

Matkovic V. Nutrition, genetics and skeletal development. J Am Coll Nutr. 1996. 15(6):556-69

Rasmussen HS, Aurup P, Goldstein K, McNair P, Mortensen PB, Larsen OG, Lawaetz H. Influence of magnesium substitution therapy on blood lipid composition in patients with ischemic heart disease. A double-blind, placebo controlled study. Arch Intern Med. 1989 May;149(5):1050-3.

Rude RK and Olerich M. Magnesium deficiency: Possible role in osteoporosis associated with gluten-sensitive enteropathy. Osteoporos Int 1996;6:453-61.

Sojka JE, Weaver CM. Magnesium supplementation and osteoporosis. Nutr Rev. 1995 Mar;53(3):71-4.

Tanabe K, Yamamoto A, Suzuki N, Osada N, Yokoyama Y, Samejima H, Seki A, Oya M, Murabayashi T, Nakayama M, Yamamoto M, Omiya K, Itoh H, Murayama M. Efficacy of oral magnesium administration on decreased exercise tolerance in a state of chronic sleep deprivation. Jpn Circ J. 1998 May;62(5):341-6.

= Vegetarian Formula

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